Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03876 |
PTGFRN Protein, Cynomolgus, Recombinant (His)
prostaglandin F2 receptor inhibitor |
Cynomolgus | HEK293 Cells |
EWI-F, also known as PTGFRN, is inversely related to the loss of CD9. Its expression correlates with the metastatic status of hLT. EWI-F inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. EWI-F expression positively correlates with the metastatic status of hLT, and that the upregulation of EWI-F expression could be one of the mechanisms underlying the loss of CD9 in solid tumours. |